Recombinant Adeno-Associated Virus-Mediated Delivery of MicroRNA-21-3p Lowers Hypertension

Recombinant Adeno-Associated Virus-Mediated Delivery of MicroRNA-21-3p Lowers Hypertension

Hypertension is the most important risk factor for cardiovascular diseases worldwide. However, the underlying molecular mechanisms of hypertension are complex and remain largely elusive. Here, we described a novel, microRNA-dependent therapeutic strategy for hypertension. First, we found that plasma...

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Bibliographic Details
Main Authors: Feng Wang, Qin Fang, Chen Chen, Ling Zhou, Huaping Li, Zhongwei Yin, Yan Wang, Chun Xia Zhao, Xiao Xiao, Dao Wen Wang
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
rAAV
miR-21-3p
hypertension
ADRA2B
VSMC
vascular remodeling
α-SMA
OPN
NF-κB
SRF
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117302913

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http://www.sciencedirect.com/science/article/pii/S2162253117302913

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