Epigenetic inactivation of the miR-124-1 in haematological malignancies.

Epigenetic inactivation of the miR-124-1 in haematological malignancies.

miR-124-1 is a tumour suppressor microRNA (miR). Epigenetic deregulation of miRs is implicated in carcinogenesis. Promoter DNA methylation and histone modification of miR-124-1 was studied in 5 normal marrow controls, 4 lymphoma, 8 multiple myeloma (MM) cell lines, 230 diagnostic primary samples of...

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Bibliographic Details
Main Authors: Kwan Yeung Wong, Chi Chiu So, Florence Loong, Lap Ping Chung, William Wai Lung Lam, Raymond Liang, George Kam Hop Li, Dong-Yan Jin, Chor Sang Chim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3081325?pdf=render

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http://europepmc.org/articles/PMC3081325?pdf=render

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