Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis

Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis

Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate, controls important events, including the release of inflammatory mediators, mammalian target of rapamycin (mTOR) activation, and autophagy. However, its role in macrophages remains elusive. We report that pharmacologic inhi...

Full description

Bibliographic Details
Main Authors: Erika M. Palmieri, Alessio Menga, Rosa Martín-Pérez, Annamaria Quinto, Carla Riera-Domingo, Giacoma De Tullio, Douglas C. Hooper, Wouter H. Lamers, Bart Ghesquière, Daniel W. McVicar, Attilio Guarini, Massimiliano Mazzone, Alessandra Castegna
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
glutamine
glutamine synthetase
macrophages
succinate
HIF1α
metastasis
IL-10
starvation
metabolic rewiring
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717310331

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717310331

Similar Items