Mitochondrial-Derived Vesicles as Candidate Biomarkers in Parkinson’s Disease: Rationale, Design and Methods of the EXosomes in PArkiNson Disease (EXPAND) Study

Mitochondrial-Derived Vesicles as Candidate Biomarkers in Parkinson’s Disease: Rationale, Design and Methods of the EXosomes in PArkiNson Disease (EXPAND) Study

The progressive loss of dopaminergic neurons in the nigro-striatal system is a major trait of Parkinson’s disease (PD), manifesting clinically as motor and non-motor symptoms. Mitochondrial dysfunction and oxidative stress are alleged pathogenic mechanisms underlying aggregation of misfold...

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Bibliographic Details
Main Authors: Anna Picca, Flora Guerra, Riccardo Calvani, Cecilia Bucci, Maria Rita Lo Monaco, Anna Rita Bentivoglio, Francesco Landi, Roberto Bernabei, Emanuele Marzetti
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
exosomes
mitophagy
mitochondrial quality control
mitochondrial-lysosomal axis
mtDNA
extracellular vesicles
Online Access:https://www.mdpi.com/1422-0067/20/10/2373

Internet

https://www.mdpi.com/1422-0067/20/10/2373

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