Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model

Recent data suggest that cholesterol metabolism is linked to susceptibility to Alzheimer's disease (AD). However, no direct evidence has been reported linking cholesterol metabolism and the pathogenesis of AD. To test the hypothesis that amyloid β-peptide (Aβ) deposition can be modulated by die...

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Bibliographic Details
Main Authors: Lorenzo M. Refolo, Miguel A. Pappolla, Brian Malester, John LaFrancois, Tara Bryant-Thomas, Rong Wang, G.Stephen Tint, Kumar Sambamurti, Karen Duff
Format: Article
Language:English
Published: Elsevier 2000-08-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996100903048