Loss of BAP1 Is Associated with Upregulation of the NFkB Pathway and Increased HLA Class I Expression in Uveal Melanoma

Loss of BAP1 Is Associated with Upregulation of the NFkB Pathway and Increased HLA Class I Expression in Uveal Melanoma

One of the characteristics of prognostically infaust uveal melanoma (UM) is an inflammatory phenotype, which is characterized by high numbers of infiltrating T cells and macrophages, and a high HLA Class I expression. We wondered how this inflammation is regulated, and considered that one of the mos...

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Bibliographic Details
Main Authors: Zahra Souri, Annemijn P. A. Wierenga, Christiaan van Weeghel, Pieter A. van der Velden, Wilma G. M. Kroes, Gregorius P. M. Luyten, Sjoerd H. van der Burg, Aart G. Jochemsen, Martine J. Jager
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
uveal melanoma
inflammation
HLA Class I
NFkB pathway
BAP1
oncology
Online Access:https://www.mdpi.com/2072-6694/11/8/1102

Internet

https://www.mdpi.com/2072-6694/11/8/1102

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