Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity

Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity

Objective: NAD+ is a co-factor and substrate for enzymes maintaining energy homeostasis. Nicotinamide phosphoribosyltransferase (NAMPT) controls NAD+ synthesis, and in skeletal muscle, NAD+ is essential for muscle integrity. However, the underlying molecular mechanisms by which NAD+ synthesis affect...

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Bibliographic Details
Main Authors: Astrid L. Basse, Marianne Agerholm, Jean Farup, Emilie Dalbram, Joachim Nielsen, Niels Ørtenblad, Ali Altıntaş, Amy M. Ehrlich, Thomas Krag, Santina Bruzzone, Morten Dall, Roldan M. de Guia, Jonas B. Jensen, Andreas B. Møller, Anders Karlsen, Michael Kjær, Romain Barrès, John Vissing, Steen Larsen, Niels Jessen, Jonas T. Treebak
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Molecular Metabolism
Subjects:
Cyclophilin D
Mitochondrial permeability transition pore (mPTP)
Myopathy
NAD+
Nicotinamide riboside
Sarcopenia
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821001162

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http://www.sciencedirect.com/science/article/pii/S2212877821001162

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