Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport.

Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport.

Despite overwhelming evidence implicating the prion protein (PrP) in prion disease pathogenesis, the normal function of this cell surface glycoprotein remains unclear. In previous reports we demonstrated that PrP mediates cellular iron uptake and transport, and aggregation of PrP to the disease caus...

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Bibliographic Details
Main Authors: Ajay Singh, Qingzhong Kong, Xiu Luo, Robert B Petersen, Howard Meyerson, Neena Singh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2699477?pdf=render

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http://europepmc.org/articles/PMC2699477?pdf=render

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