OGP46 Induces Differentiation of Acute Myeloid Leukemia Cells via Different Optimal Signaling Pathways

OGP46 Induces Differentiation of Acute Myeloid Leukemia Cells via Different Optimal Signaling Pathways

Acute myelogenous leukemia (AML) is characterized by blockage of cell differentiation leading to the accumulation of immature cells, which is the most prevalent form of acute leukemia in adults. It is well known that all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) are the preferred drugs f...

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Bibliographic Details
Main Authors: Min Zhao, Jiangyun Wang, Mei Qu, Yao Zhao, Haihua Wang, Yu Ke, Ying Liu, Zi-Ning Lei, Hong-Min Liu, Zhenbo Hu, Liuya Wei, Zhe-Sheng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
acute myeloid leukemia
acute promyelocytic leukemia
differentiation therapy
AML cells with t(8;21) translocation
PML-RARα depletion
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.652972/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.652972/full

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