Targeted Promoter Replacement Reveals That Herpes Simplex Virus Type-1 and 2 Specific VP16 Promoters Direct Distinct Rates of Entry Into the Lytic Program in Sensory Neurons in vivo

Targeted Promoter Replacement Reveals That Herpes Simplex Virus Type-1 and 2 Specific VP16 Promoters Direct Distinct Rates of Entry Into the Lytic Program in Sensory Neurons in vivo

Infection and life-long residence in the human nervous system is central to herpes simplex virus (HSV) pathogenesis. Access is gained through innervating axonal projections of sensory neurons. This distinct mode of entry separates the viral genome from tegument proteins, including the potent transac...

Full description

Bibliographic Details
Main Authors: Richard L. Thompson, Nancy M. Sawtell
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Microbiology
Subjects:
herpes simplex virus
latent program
sensory neuron
HSV-1 and HSV-2 VP16 promoter
regulation
corneal infection model
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01624/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.01624/full

Similar Items