Titanium Dioxide Nanoparticles Enhance Leakiness and Drug Permeability in Primary Human Hepatic Sinusoidal Endothelial Cells

Titanium Dioxide Nanoparticles Enhance Leakiness and Drug Permeability in Primary Human Hepatic Sinusoidal Endothelial Cells

Liver sinusoidal endothelial cells (LSECs) represent the permeable interface that segregates the blood compartment from the hepatic cells, regulating hepatic vascular tone and portal pressure amidst changes in the blood flow. In the presence of pathological conditions, phenotypic changes in LSECs co...

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Bibliographic Details
Main Authors: Jie Kai Tee, Li Yang Ng, Hannah Yun Koh, David Tai Leong, Han Kiat Ho
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:International Journal of Molecular Sciences
Subjects:
cell–material interaction
titanium dioxide nanoparticles
liver sinusoidal endothelial cells
endothelial permeability
oxidative stress
Akt pathway
cell attachment
liver fibrosis
Online Access:http://www.mdpi.com/1422-0067/20/1/35

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http://www.mdpi.com/1422-0067/20/1/35

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