Haploidentical Stem Cell Transplantation in Children With Hematological Malignancies Using αβ+ T-Cell Receptor and CD19+ Cell Depleted Grafts: High CD56dim/CD56bright NK Cell Ratio Early Following Transplantation Is Associated With Lower Relapse Incidence and Better Outcome

Haploidentical Stem Cell Transplantation in Children With Hematological Malignancies Using αβ+ T-Cell Receptor and CD19+ Cell Depleted Grafts: High CD56dim/CD56bright NK Cell Ratio Early Following Transplantation Is Associated With Lower Relapse Incidence and Better Outcome

We prospectively analyzed outcomes of haploidentical hematopoietic stem cell transplantation using αβ+ T-cell receptor/CD19+ depleted grafts. Sixty-three transplantations were performed in 60 patients. Twenty-eight patients were diagnosed with acute lymphoblastic leukemia (ALL), 27 patients were dia...

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Bibliographic Details
Main Authors: Miguel A. Diaz, Josune Zubicaray, Blanca Molina, Lorea Abad, Ana Castillo, Elena Sebastian, Eva Galvez, Julia Ruiz, Jose Luis Vicario, Manuel Ramirez, Julian Sevilla, Marta González-Vicent
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
T-cell depletion
NK cells
haploidentical transplantation
immune reconstitution
acute leukemia
children
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02504/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02504/full

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