The Effect of β-Glycerophosphate Crosslinking on Chitosan Cytotoxicity and Properties of Hydrogels for Vaginal Application

The Effect of β-Glycerophosphate Crosslinking on Chitosan Cytotoxicity and Properties of Hydrogels for Vaginal Application

Mucoadhesive gelling systems based on chitosan and chitosan/β-glycerophosphate (β-GP) were developed in order to increase clotrimazole residence time in the vaginal cavity. Ex vivo mucoadhesiveness using porcine vaginal mucosa followed with mechanical, viscoelastic, and swelling properties of prepar...

Full description

Bibliographic Details
Main Authors: Emilia Szymaǹska, Katarzyna Sosnowska, Wojciech Miltyk, Małgorzata Rusak, Anna Basa, Katarzyna Winnicka
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:Polymers
Subjects:
hitosan
β-glycerophosphate
ion crosslinking
mucoadhesion
cytotoxicity
CRL 2616 cell line
Online Access:http://www.mdpi.com/2073-4360/7/11/1510

Internet

http://www.mdpi.com/2073-4360/7/11/1510

Similar Items