Synthesis and Characterization of Some New Quinoxalin-2(<i>1H</i>)one and 2-Methyl-3<i>H</i>-quinazolin-4-one Derivatives Targeting the Onset and Progression of CRC with SRA, Molecular Docking, and ADMET Analyses

Synthesis and Characterization of Some New Quinoxalin-2(<i>1H</i>)one and 2-Methyl-3<i>H</i>-quinazolin-4-one Derivatives Targeting the Onset and Progression of CRC with SRA, Molecular Docking, and ADMET Analyses

The pathogenesis of colorectal cancer is a multifactorial process. Dysbiosis and the overexpression of COX-2 and LDHA are important effectors in the initiation and development of the disease through chromosomal instability, PGE2 biosynthesis, and induction of the Warburg effect, respectively. Herein...

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Bibliographic Details
Main Authors: Nahed N. E. El-Sayed, Taghreed M. Al-Otaibi, Mona Alonazi, Vijay H. Masand, Assem Barakat, Zainab M. Almarhoon, Abir Ben Bacha
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
colorectal cancer
dysbiosis
cyclooxygenase-2
lactate dehydrogenase A
quinazoline
quinoxaline
Online Access:https://www.mdpi.com/1420-3049/26/11/3121

Internet

https://www.mdpi.com/1420-3049/26/11/3121

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