Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells

Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells

MEF2D-fusion (M-fusion) genes are newly discovered recurrent gene abnormalities that are detected in approximately 5 % of acute lymphoblastic leukemia (ALL) cases. Their introduction to cells has been reported to transform cell lines or increase the colony formation of bone marrow cells, suggesting...

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Bibliographic Details
Main Authors: Naoyuki Tange, Fumihiko Hayakawa, Takahiko Yasuda, Koya Odaira, Hideyuki Yamamoto, Daiki Hirano, Toshiyasu Sakai, Seitaro Terakura, Shinobu Tsuzuki, Hitoshi Kiyoi
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
MEF2D
High throughput screening
Acute lymphoblastic leukemia
Staurosporine
Drug repositioning
Drug discovery
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220305229

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http://www.sciencedirect.com/science/article/pii/S0753332220305229

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