PTPN13 and β-Catenin Regulate the Quiescence of Hematopoietic Stem Cells and Their Interaction with the Bone Marrow Niche

PTPN13 and β-Catenin Regulate the Quiescence of Hematopoietic Stem Cells and Their Interaction with the Bone Marrow Niche

The regulation of hematopoietic stem cells (HSCs) depends on the integration of the multiple signals received from the bone marrow niche. We show the relevance of the protein tyrosine phosphatase PTPN13 and β-catenin as intracellular signaling molecules to control HSCs adhesiveness, cell cycling, an...

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Bibliographic Details
Main Authors: Guillermo López-Ruano, Rodrigo Prieto-Bermejo, Teresa L. Ramos, Laura San-Segundo, Luis Ignacio Sánchez-Abarca, Fermín Sánchez-Guijo, José Antonio Pérez-Simón, Jesús Sánchez-Yagüe, Marcial Llanillo, Ángel Hernández-Hernández
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115002374

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http://www.sciencedirect.com/science/article/pii/S2213671115002374

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