Losartan protects against osteoarthritis by repressing the TGF-β1 signaling pathway via upregulation of PPARγ

Losartan protects against osteoarthritis by repressing the TGF-β1 signaling pathway via upregulation of PPARγ

Objective: Losartan and activation of the peroxisome proliferator-activated receptor-γ (PPARγ) have been previously reported to alleviate the progression of osteoarthritis (OA). However, the nature of the interaction between losartan and PPARγ in OA remains elusive. Therefore, we aimed to investigat...

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Bibliographic Details
Main Authors: Zhenhan Deng, MD, Ph.D, Fei Chen, Ph.D, Yuwei Liu, MD, Ph.D, Jinping Wang, Ph.D, Wei Lu, MD, Ph.D, Wei Jiang, MD, Ph.D, Weimin Zhu, MD, Ph.D
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Journal of Orthopaedic Translation
Subjects:
Osteoarthritis
Losartan
PPARγ
TGF-β1 signaling pathway
IL-1β
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X21000218

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http://www.sciencedirect.com/science/article/pii/S2214031X21000218

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