Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2.
Human breast cancer susceptibility gene, BRCA2, encodes a 3418-amino acid protein that is essential for maintaining genomic integrity. Among the proteins that physically interact with BRCA2, Partner and Localizer of BRCA2 (PALB2), which binds to the N-terminal region of BRCA2, is vital for its funct...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-08-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC4973925?pdf=render |