Mice Lacking Endoglin in Macrophages Show an Impaired Immune Response.
Endoglin is an auxiliary receptor for members of the TGF-β superfamily and plays an important role in the homeostasis of the vessel wall. Mutations in endoglin gene (ENG) or in the closely related TGF-β receptor type I ACVRL1/ALK1 are responsible for a rare dominant vascular dysplasia, the Hereditar...
Main Authors: | , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-03-01
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Series: | PLoS Genetics |
Online Access: | https://doi.org/10.1371/journal.pgen.1005935 |