Drug transporter and oxidative stress gene expression in human macrophages infected with benznidazole-sensitive and naturally benznidazole-resistant Trypanosoma cruzi parasites treated with benznidazole

Drug transporter and oxidative stress gene expression in human macrophages infected with benznidazole-sensitive and naturally benznidazole-resistant Trypanosoma cruzi parasites treated with benznidazole

Abstract Background Chagas disease is a potentially life-threatening disease caused by the protozoan parasite Trypanosoma cruzi. Current therapeutic management is limited to treatment with nitroheterocyclic drugs, such as nifurtimox (NFX) and benznidazole (BZ). Thus, the identification of affordable...

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Bibliographic Details
Main Authors: Jair Téllez, Ibeth Romero, Alvaro José Romanha, Mario Steindel
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Parasites & Vectors
Subjects:
Chagas disease
Host–pathogen interactions
Trypanosoma cruzi
Uptake
Benznidazole
Online Access:http://link.springer.com/article/10.1186/s13071-019-3485-9

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http://link.springer.com/article/10.1186/s13071-019-3485-9

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