Optimization of total protein and activity assays for the detection of MMP-12 in induced human sputum

<p>Abstract</p> <p>Background</p> <p>Proteolysis of matrix components, in particular elastin, is a major contributing factor to the development of lung diseases such as emphysema and chronic obstructive pulmonary disease (COPD). MMP-12 (macrophage elastase) is a proteas...

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Bibliographic Details
Main Authors: Sypek Joe, Miller Doug, Fleming Margaret, Grierson Christal, Brady Jeff, LaPan Peter, Fu Bin
Format: Article
Language:English
Published: BMC 2010-08-01
Series:BMC Pulmonary Medicine
Online Access:http://www.biomedcentral.com/1471-2466/10/40