Structural Insights into Phylloquinone (Vitamin K1), Menaquinone (MK4, MK7), and Menadione (Vitamin K3) Binding to VKORC1

Structural Insights into Phylloquinone (Vitamin K1), Menaquinone (MK4, MK7), and Menadione (Vitamin K3) Binding to VKORC1

Vitamin K family molecules—phylloquinone (K1), menaquinone (K2), and menadione (K3)—act as γ-glutamyl carboxylase (GGCX)-exclusive cofactors in their hydroquinone state, activating proteins of main importance for blood coagulation in the liver and for arterial calcifica...

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Bibliographic Details
Main Authors: Nolan Chatron, Abdessalem Hammed, Etienne Benoît, Virginie Lattard
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Nutrients
Subjects:
vitamins K
phylloquinone
menaquinones
menadione
VKORC1
membrane
structural interactions
molecular modeling
enzymatic assays
Online Access:http://www.mdpi.com/2072-6643/11/1/67

Internet

http://www.mdpi.com/2072-6643/11/1/67

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