Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons
<p>Abstract</p> <p>Background</p> <p>Glutathione (GSH) plays an important role in neuronal oxidant defence. Depletion of cellular GSH is observed in neurodegenerative diseases and thereby contributes to the associated oxidative stress and Ca<sup>2+ </sup>dys...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2012-04-01
|
Series: | Molecular Brain |
Subjects: | |
Online Access: | http://www.molecularbrain.com/content/5/1/11 |