Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons

Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons

<p>Abstract</p> <p>Background</p> <p>Glutathione (GSH) plays an important role in neuronal oxidant defence. Depletion of cellular GSH is observed in neurodegenerative diseases and thereby contributes to the associated oxidative stress and Ca<sup>2+ </sup>dys...

Full description

Bibliographic Details
Main Authors: Belrose Jillian C, Xie Yu-Feng, Gierszewski Lynn J, MacDonald John F, Jackson Michael F
Format: Article
Language:English
Published: BMC 2012-04-01
Series:Molecular Brain
Subjects:
TRPM2
Aging
Glutathione
Oxidative stress
Pyramidal neuron
Primary hippocampal culture
Online Access:http://www.molecularbrain.com/content/5/1/11

Similar Items

Similar Items