Spectrum and Prevalence of Pathogenic Variants in Ovarian Cancer Susceptibility Genes in a Group of 333 Patients

Spectrum and Prevalence of Pathogenic Variants in Ovarian Cancer Susceptibility Genes in a Group of 333 Patients

Constitutional loss-of-function pathogenic variants in the tumor suppressor genes <i>BRCA1</i> and <i>BRCA2</i> are widely associated with an elevated risk of ovarian cancer (OC). As only ~15% of OC individuals carry the <i>BRCA1/2</i> pathogenic variants, the ide...

Full description

Bibliographic Details
Main Authors: Magdalena Koczkowska, Natalia Krawczynska, Maciej Stukan, Alina Kuzniacka, Izabela Brozek, Marcin Sniadecki, Jaroslaw Debniak, Dariusz Wydra, Wojciech Biernat, Piotr Kozlowski, Janusz Limon, Bartosz Wasag, Magdalena Ratajska
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Cancers
Subjects:
ovarian cancer
low-penetrance gene
<i>BRCA1</i>/2
PARP1 inhibitor
next-generation sequencing
<i>CHEK2</i>
<i>NBN</i>
<i>BARD1</i>
mismatch repair genes
Online Access:https://www.mdpi.com/2072-6694/10/11/442

Internet

https://www.mdpi.com/2072-6694/10/11/442

Similar Items