Non Linear Programming (NLP) formulation for quantitative modeling of protein signal transduction pathways.

Modeling of signal transduction pathways plays a major role in understanding cells' function and predicting cellular response. Mathematical formalisms based on a logic formalism are relatively simple but can describe how signals propagate from one protein to the next and have led to the constru...

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Bibliographic Details
Main Authors: Alexander Mitsos, Ioannis N Melas, Melody K Morris, Julio Saez-Rodriguez, Douglas A Lauffenburger, Leonidas G Alexopoulos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3511450?pdf=render