Immunoglobulin G subclass and antibody avidity responses in Malian children immunized with Plasmodium falciparum apical membrane antigen 1 vaccine candidate FMP2.1/AS02A

Immunoglobulin G subclass and antibody avidity responses in Malian children immunized with Plasmodium falciparum apical membrane antigen 1 vaccine candidate FMP2.1/AS02A

Abstract Background A malaria vaccine based on Plasmodium falciparum apical membrane antigen 1 (AMA1) elicited strain specific efficacy in Malian children that waned in the second season after vaccination despite sustained AMA1 antibody titers. With the goal of identifying a humoral correlate of vac...

Full description

Bibliographic Details
Main Authors: Andrea A. Berry, Eric R. Gottlieb, Bourema Kouriba, Issa Diarra, Mahamadou A. Thera, Sheetij Dutta, Drissa Coulibaly, Amed Ouattara, Amadou Niangaly, Abdoulaye K. Kone, Karim Traore, Youssouf Tolo, Vladimir Mishcherkin, Lorraine Soisson, Carter L. Diggs, William C. Blackwelder, Matthew B. Laurens, Marcelo B. Sztein, Ogobara K. Doumbo, Christopher V. Plowe, Kirsten E. Lyke
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Malaria Journal
Subjects:
Malaria vaccine
Adjuvant
Natural exposure
Avidity
Immunoglobulin G subclass
Area under the curve
Online Access:http://link.springer.com/article/10.1186/s12936-019-2637-x

Internet

http://link.springer.com/article/10.1186/s12936-019-2637-x

Similar Items