Toddalolactone Protects Lipopolysaccharide-Induced Sepsis and Attenuates Lipopolysaccharide-Induced Inflammatory Response by Modulating HMGB1-NF-κB Translocation

Toddalolactone Protects Lipopolysaccharide-Induced Sepsis and Attenuates Lipopolysaccharide-Induced Inflammatory Response by Modulating HMGB1-NF-κB Translocation

Toddalolactone (TA-8) is a main compound isolated from Toddalia asiatica (L.) Lam., and its anti-inflammatory activity and anti-inflammatory mechanism are less studied. In the present study, we investigated the anti-inflammatory effects of TA-8. Our experimental results showed that TA-8 inhibited th...

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Bibliographic Details
Main Authors: Jingyu Ni, Yuxuan Zhao, Jing Su, Zhihao Liu, Shiming Fang, Lan Li, Jie Deng, Guanwei Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
toddalolactone
NF-kappa B pathway
HMGB1
inflammation
sepsis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00109/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00109/full

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