Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses

Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses

<p>Abstract</p> <p>Background</p> <p>Chronic asthma is often associated with neutrophilic infiltration in the airways. Neutrophils contain elastase, a potent secretagogue in the airways, nonetheless the role for neutrophil elastase as well as neutrophilic inflammation i...

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Bibliographic Details
Main Authors: Koga Hikari, Miyahara Nobuaki, Fuchimoto Yasuko, Ikeda Genyo, Waseda Koichi, Ono Katsuichiro, Tanimoto Yasushi, Kataoka Mikio, Gelfand Erwin W, Tanimoto Mitsune, Kanehiro Arihiko
Format: Article
Language:English
Published: BMC 2013-01-01
Series:Respiratory Research
Subjects:
Neutrophil
Elastase
Airway
Hyperresponsiveness
Asthma
Online Access:http://respiratory-research.com/content/14/1/8

Internet

http://respiratory-research.com/content/14/1/8

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