Current Understanding of Molecular Pathology and Treatment of Cardiomyopathy in Duchenne Muscular Dystrophy

Current Understanding of Molecular Pathology and Treatment of Cardiomyopathy in Duchenne Muscular Dystrophy

Duchenne muscular dystrophy (DMD) is a genetic muscle disorder caused by mutations in the Dmd gene resulting in the loss of the protein dystrophin. Patients do not only experience skeletal muscle degeneration, but also develop severe cardiomyopathy by their second decade, one of the main causes of d...

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Bibliographic Details
Main Authors: Tirsa L. E. van Westering, Corinne A. Betts, Matthew J. A. Wood
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:Molecules
Subjects:
heart
dystrophin
calcium
nNOS
mitochondria
utrophin up-regulation
read-through
viral gene therapy
cell-based therapy
exon skipping
Online Access:http://www.mdpi.com/1420-3049/20/5/8823

Internet

http://www.mdpi.com/1420-3049/20/5/8823

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