RTA‐408 protects against propofol‐induced cognitive impairment in neonatal mice via the activation of Nrf2 and the inhibition of NF‐κB p65 nuclear translocation

Abstract Objective To explore the effect of RTA‐408 on the propofol‐induced cognitive impairment of neonatal mice via regulating Nrf2 and NF‐κB p65 nuclear translocation. Methods C57BL/6 neonatal mice were randomized into intralipid, propofol, vehicle + propofol, and RTA‐408 + propofol groups. The l...

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Bibliographic Details
Main Authors: Ling Zhang, Qian Zhou, Chun‐Li Zhou
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Brain and Behavior
Subjects:
Online Access:https://doi.org/10.1002/brb3.1918