Thrombin and factor Xa link the coagulation system with liver fibrosis

Thrombin and factor Xa link the coagulation system with liver fibrosis

Abstract Background Thrombin activates hepatic stellate cells via protease-activated receptor-1. The role of Factor Xa (FXa) in hepatic fibrosis has not been elucidated. We aimed to evaluate the impact of FXa and thrombin in vitro on stellate cells and their respective inhibition in vivo using a rod...

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Bibliographic Details
Main Authors: Ameet Dhar, Fouzia Sadiq, Quentin M. Anstee, Adam P. Levene, Robert D. Goldin, Mark R. Thursz
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Gastroenterology
Subjects:
Fibrosis
Hepatic stellate cell
Thrombin
Factor Xa
Anticoagulation
Online Access:http://link.springer.com/article/10.1186/s12876-018-0789-8

Internet

http://link.springer.com/article/10.1186/s12876-018-0789-8

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