Klotho/FGF23 axis mediates high phosphate‐induced vascular calcification in vascular smooth muscle cells via Wnt7b/β‐catenin pathway

Klotho/FGF23 axis mediates high phosphate‐induced vascular calcification in vascular smooth muscle cells via Wnt7b/β‐catenin pathway

Abstract Vascular calcification (VC) plays as a critical role on cardiovascular disease (CVD) and acts as a notable risk factor in cardiovascular system. Vascular smooth muscle cells (VSMCs) calcification can be triggered by high phosphate treatment; however, the explicit mechanism remains unclear....

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Bibliographic Details
Main Authors: Yan‐Xia Chen, Chong Huang, Zhi‐Bing Duan, Cheng‐Yun Xu, Yan Chen
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:Kaohsiung Journal of Medical Sciences
Subjects:
FGF23
high phosphate
Klotho
vascular calcification
Wnt7b/β‐catenin
Online Access:https://doi.org/10.1002/kjm2.12072

Internet

https://doi.org/10.1002/kjm2.12072

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