Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors

Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors

The metabotropic glutamate receptors (mGluRs) form a family of neuromodulatory G-protein-coupled receptors that contain both a seven-helix transmembrane domain (TMD) and a large extracellular ligand-binding domain (LBD) which enables stable dimerization. Although numerous studies have revealed varia...

Full description

Bibliographic Details
Main Authors: Jordana K Thibado, Jean-Yves Tano, Joon Lee, Leslie Salas-Estrada, Davide Provasi, Alexa Strauss, Joao Marcelo Lamim Ribeiro, Guoqing Xiang, Johannes Broichhagen, Marta Filizola, Martin J Lohse, Joshua Levitz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
GPCR
single molecule fluorescence
conformational dynamics
dimerization
metabotropic glutamate receptor
molecular dynamics
Online Access:https://elifesciences.org/articles/67027

Internet

https://elifesciences.org/articles/67027

Similar Items