TRIM47 is up-regulated in colorectal cancer, promoting ubiquitination and degradation of SMAD4

TRIM47 is up-regulated in colorectal cancer, promoting ubiquitination and degradation of SMAD4

Abstract Background Tripartite motif 47 (TRIM47), a member of the TRIM family proteins, plays a key role in many types of cancers including colorectal cancer (CRC). We found that levels of TRIM47 mRNA and protein were increased significantly in colorectal tumors compared with nontumor tissues and th...

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Bibliographic Details
Main Authors: Qian Liang, Chaotao Tang, Mingyu Tang, Qingwei Zhang, Yunjie Gao, Zhizheng Ge
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colorectal carcinoma
E3 ubiquitin ligase
Proliferation
Metastasis
TRIM47
Online Access:http://link.springer.com/article/10.1186/s13046-019-1143-x

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http://link.springer.com/article/10.1186/s13046-019-1143-x

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