Causal interactions from proteomic profiles: Molecular data meet pathway knowledge

Causal interactions from proteomic profiles: Molecular data meet pathway knowledge

Summary: We present a computational method to infer causal mechanisms in cell biology by analyzing changes in high-throughput proteomic profiles on the background of prior knowledge captured in biochemical reaction knowledge bases. The method mimics a biologist's traditional approach of explain...

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Bibliographic Details
Main Authors: Özgün Babur, Augustin Luna, Anil Korkut, Funda Durupinar, Metin Can Siper, Ugur Dogrusoz, Alvaro Sebastian Vaca Jacome, Ryan Peckner, Karen E. Christianson, Jacob D. Jaffe, Paul T. Spellman, Joseph E. Aslan, Chris Sander, Emek Demir
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Patterns
Subjects:
proteomics
causal pathway analysis
cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2666389921000830

Internet

http://www.sciencedirect.com/science/article/pii/S2666389921000830

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