Causal interactions from proteomic profiles: Molecular data meet pathway knowledge
Summary: We present a computational method to infer causal mechanisms in cell biology by analyzing changes in high-throughput proteomic profiles on the background of prior knowledge captured in biochemical reaction knowledge bases. The method mimics a biologist's traditional approach of explain...
Main Authors: | Özgün Babur, Augustin Luna, Anil Korkut, Funda Durupinar, Metin Can Siper, Ugur Dogrusoz, Alvaro Sebastian Vaca Jacome, Ryan Peckner, Karen E. Christianson, Jacob D. Jaffe, Paul T. Spellman, Joseph E. Aslan, Chris Sander, Emek Demir |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021-06-01
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Series: | Patterns |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2666389921000830 |
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