Mechanisms and rejuvenation strategies for aged hematopoietic stem cells

Mechanisms and rejuvenation strategies for aged hematopoietic stem cells

Abstract Hematopoietic stem cell (HSC) aging, which is accompanied by reduced self-renewal ability, impaired homing, myeloid-biased differentiation, and other defects in hematopoietic reconstitution function, is a hot topic in stem cell research. Although the number of HSCs increases with age in bot...

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Bibliographic Details
Main Authors: Xia Li, Xiangjun Zeng, Yulin Xu, Binsheng Wang, Yanmin Zhao, Xiaoyu Lai, Pengxu Qian, He Huang
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Hematology & Oncology
Subjects:
Hematopoietic stem cells
Aging
Single-cell sequencing
Epigenetics
Rejuvenation
Online Access:http://link.springer.com/article/10.1186/s13045-020-00864-8

Internet

http://link.springer.com/article/10.1186/s13045-020-00864-8

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