Rational Design of an Orthogonal Pair of Bimolecular RNase P Ribozymes through Heterologous Assembly of Their Modular Domains

Rational Design of an Orthogonal Pair of Bimolecular RNase P Ribozymes through Heterologous Assembly of Their Modular Domains

The modular structural domains of multidomain RNA enzymes can often be dissected into separate domain RNAs and their noncovalent assembly can often reconstitute active enzymes. These properties are important to understand their basic characteristics and are useful for their application to RNA-based...

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Bibliographic Details
Main Authors: Yuri Nozawa, Megumi Hagihara, Md Sohanur Rahman, Shigeyoshi Matsumura, Yoshiya Ikawa
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Biology
Subjects:
modular engineering
ribonuclease P
ribozyme
tRNA processing
Online Access:https://www.mdpi.com/2079-7737/8/3/65

Internet

https://www.mdpi.com/2079-7737/8/3/65

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