Evidence Suggesting Absence of Mitochondrial DNA Methylation

Methylation of nuclear genes encoding mitochondrial proteins participates in the regulation of mitochondria function. The existence of cytosine methylation in the mitochondrial genome is debated. To investigate whether mitochondrial DNA (mtDNA) is methylated, we used both targeted- and whole mitocho...

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Bibliographic Details
Main Authors: Mie Mechta, Lars R. Ingerslev, Odile Fabre, Martin Picard, Romain Barrès
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Genetics
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fgene.2017.00166/full