Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products

Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products

The discovery and development of multistage antimalarial drugs targeting intra-erythrocytic asexual and sexual Plasmodium falciparum parasites is of utmost importance to achieve the ambitious goal of malaria elimination. Here, we report the validation of naphthylisoquinoline (NIQ) alkaloids and thei...

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Bibliographic Details
Main Authors: Phanankosi Moyo, William Shamburger, Mariëtte E. van der Watt, Janette Reader, Ana Carolina C. de Sousa, Timothy J. Egan, Vinesh J. Maharaj, Gerhard Bringmann, Lyn-Marie Birkholtz
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Naphthylisoquinoline alkaloids
Natural products
Hit validation
Plasmodium falciparum
Malaria
Multistage active antimalarial drug candidates
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320720300130

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http://www.sciencedirect.com/science/article/pii/S2211320720300130

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