Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction

Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction

Acidotoxicity is common among neurological disorders, such as ischemic stroke. Traditionally, Ca2+ influx via homomeric acid-sensing ion channel 1a (ASIC1a) was considered to be the leading cause of ischemic acidotoxicity. Here we show that extracellular protons trigger a novel form of neuronal necr...

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Bibliographic Details
Main Authors: Yi-Zhi Wang, Jing-Jing Wang, Yu Huang, Fan Liu, Wei-Zheng Zeng, Ying Li, Zhi-Gang Xiong, Michael X Zhu, Tian-Le Xu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-11-01
Series:eLife
Subjects:
ion channel
ischemic stroke
necroptosis
acidotoxicity
ASIC1a
neuroprotection
Online Access:https://elifesciences.org/articles/05682

Internet

https://elifesciences.org/articles/05682

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