Do Somatic Mitochondrial DNA Mutations Contribute to Parkinson's Disease?

A great deal of evidence supports a role for mitochondrial dysfunction in the pathogenesis of Parkinson's disease (PD), although the origin of the mitochondrial dysfunction in PD remains unclear. Expression of mitochondrial DNA (mtDNA) from PD patients in “cybrid” cell lines recapitulates the m...

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Bibliographic Details
Main Authors: Joanne Clark, Ying Dai, David K. Simon
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Parkinson's Disease
Online Access:http://dx.doi.org/10.4061/2011/659694