Synthesis and Physicochemical Characterization of the Process-Related Impurities of Eplerenone, an Antihypertensive Drug

Synthesis and Physicochemical Characterization of the Process-Related Impurities of Eplerenone, an Antihypertensive Drug

Two unknown impurities were observed during the process development for multigram-scale synthesis of eplerenone (Inspra®). The new process-related impurities were identified and fully characterized as the corresponding (7β,11α,17α)-11-hydroxy- and (7α,11β,17α)-9,11-dichloroeplerenone derivatives 12a...

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Bibliographic Details
Main Authors: Iwona Dams, Agata Białońska, Piotr Cmoch, Małgorzata Krupa, Anita Pietraszek, Anna Ostaszewska, Michał Chodyński
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Molecules
Subjects:
selective aldosterone blocker
hypertension
steroids
eplerenone
impurities
spectroscopic methods
crystal structure
Online Access:https://www.mdpi.com/1420-3049/22/8/1354

Internet

https://www.mdpi.com/1420-3049/22/8/1354

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