Sensing Acute Cellular Rejection in Liver Transplant Patients Using Liver-Derived Extracellular Particles: A Prospective, Observational Study

Sensing Acute Cellular Rejection in Liver Transplant Patients Using Liver-Derived Extracellular Particles: A Prospective, Observational Study

Acute cellular rejection (ACR) after liver transplantation (LT) goes along with allograft dysfunction, which is diagnosed by liver biopsy and concomitant histological analysis, representing the gold standard in clinical practice. Yet, liver biopsies are invasive, costly, time-intensive and require e...

Full description

Bibliographic Details
Main Authors: Kaan Kamali, Moritz Schmelzle, Can Kamali, Philipp Brunnbauer, Katrin Splith, Annekatrin Leder, Nadja Berndt, Karl-Herbert Hillebrandt, Nathanael Raschzok, Linda Feldbrügge, Matthäus Felsenstein, Joseph Gaßner, Paul Ritschl, Georg Lurje, Wenzel Schöning, Christian Benzing, Johann Pratschke, Felix Krenzien
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
acute cellular liver transplant rejection
extracellular particles (EP)
FlowSOM
liver transplantation
liquid biopsy
t-SNE (t-Distributed Stochastic Neighbor Embedding)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.647900/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.647900/full

Similar Items