Restoration of Sarcoplasmic Reticulum Ca<sup>2+</sup> ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice

Restoration of Sarcoplasmic Reticulum Ca<sup>2+</sup> ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice

Sarcopenia has a significant negative impact on healthspan in the elderly and effective pharmacologic interventions remain elusive. We have previously demonstrated that sarcopenia is associated with reduced activity of the sarcoplasmic reticulum Ca<sup>2+</sup> ATPase (SERCA) pump. We as...

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Bibliographic Details
Main Authors: Rizwan Qaisar, Gavin Pharaoh, Shylesh Bhaskaran, Hongyang Xu, Rojina Ranjit, Jan Bian, Bumsoo Ahn, Constantin Georgescu, Jonathan D. Wren, Holly Van Remmen
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
skeletal muscle
sarcoplasmic reticulum calcium-transporting ATPase
sarcopenia
Online Access:https://www.mdpi.com/1422-0067/22/1/37

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https://www.mdpi.com/1422-0067/22/1/37

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