Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics.

Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics.

Talin is a large (∼2540 residues) dimeric adaptor protein that associates with the integrin family of cell adhesion molecules in cell-extracellular matrix junctions (focal adhesions; FAs), where it both activates integrins and couples them to the actin cytoskeleton. Calpain2-mediated cleavage of tal...

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Bibliographic Details
Main Authors: Neil Bate, Alexandre R Gingras, Alexia Bachir, Rick Horwitz, Feng Ye, Bipin Patel, Benjamin T Goult, David R Critchley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3319578?pdf=render

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http://europepmc.org/articles/PMC3319578?pdf=render

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