VNTR-DAT1 and COMTVal158Met genotypes modulate mental flexibility and adaptive behavior skills in Down syndrome

VNTR-DAT1 and COMTVal158Met genotypes modulate mental flexibility and adaptive behavior skills in Down syndrome

Down syndrome (DS) is an aneuploidy syndrome that is caused by trisomy for human chromosome 21 resulting in a characteristic cognitive and behavioral phenotype, which includes executive functioning and adaptive behavior difficulties possibly due to prefrontal cortex (PFC) deficits. DS also present a...

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Bibliographic Details
Main Authors: Laura Del Hoyo, Laura Xicota, Klaus Langohr, Gonzalo Sánchez-Benavides, Susana De Sola, Aida M Cuenca-Royo, Joan Rodriguez, Josep Rodriguez, Magi Farre, Mara Dierssen, Rafael De La Torre
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Dopamine
Down Syndrome
PFC-dependent cognition
COMTVal158Met
VNTR-DAT1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2016.00193/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2016.00193/full

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