Genetic Association between Presenilin 2 Polymorphisms and Alzheimer's Disease and Dementia of Lewy Body Type in a Japanese Population

Genetic Association between Presenilin 2 Polymorphisms and Alzheimer's Disease and Dementia of Lewy Body Type in a Japanese Population

Background/Aims: Mutations in the presenilin 2 (PSEN2) gene cause familial Alzheimer's disease (AD). Common polymorphisms affect gene activity and increase the risk of AD. Nonsynonymous polymorphisms in the PSEN2 gene showed Lewy body dementia (LBD) phenotypes clinically. Therefore, we aimed to...

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Bibliographic Details
Main Authors: Ayako Suzuki, Nobuto Shibata, Koji Kasanuki, Tomoyuki Nagata, Shunichiro Shinagawa, Nobuyuki Kobayashi, Tohru Ohnuma, Yoshihide Takeshita, Eri Kawai, Toshiki Takayama, Kenya Nishioka, Yumiko Motoi, Nobutaka Hattori, Kazuhiko Nakayama, Hisashi Yamada, Heii Arai
Format: Article
Language:English
Published: Karger Publishers 2016-03-01
Series:Dementia and Geriatric Cognitive Disorders Extra
Subjects:
Presenilin 2
Apolipoprotein E
Single nucleotide polymorphism
Alzheimer’s disease
Lewy body dementia
Online Access:http://www.karger.com/Article/FullText/444080

Internet

http://www.karger.com/Article/FullText/444080

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