Spatial and functional heterogeneities shape collective behavior of tumor-immune networks.

Tumor growth involves a dynamic interplay between cancer cells and host cells, which collectively form a tumor microenvironmental network that either suppresses or promotes tumor growth under different conditions. The transition from tumor suppression to tumor promotion is mediated by a tumor-induce...

Full description

Bibliographic Details
Main Authors: Daniel K Wells, Yishan Chuang, Louis M Knapp, Dirk Brockmann, William L Kath, Joshua N Leonard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-04-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4408028?pdf=render